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UniProt functional annotation for P02724 | ||
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| UniProt code: P02724. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:15331714, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:8009226}. |
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| Subunit: | |
Homodimer. {ECO:0000269|PubMed:11313283, ECO:0000269|PubMed:1463744}. |
| Subunit: | |
(Microbial infection) Interacts with Streptococcus gordonii hsa protein. {ECO:0000269|PubMed:18380804}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:11402026}; Single-pass type I membrane protein {ECO:0000269|PubMed:11402026}. Note=Appears to be colocalized with SLC4A1. |
| Ptm: | |
The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)- [NeuAc-alpha-(2-6)]-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal- beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha- (2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)- NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)- Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal- beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha- (2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1- 2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific). {ECO:0000269|PubMed:10912628, ECO:0000269|PubMed:15313217, ECO:0000269|PubMed:3624241, ECO:0000269|PubMed:5350948, ECO:0000269|PubMed:8286855}. |
| Polymorphism: | |
Along with GYPB, GYPA is responsible for the MNS blood group system [MIM:111300]. The molecular basis of the GPA M/N bloodgroup antigen is a variation at positions 20 and 24. Ser-20 and Gly-24 correspond to M (shown); 'Leu-20' and 'Glu-24' correspond to N. |
| Polymorphism: | |
GYPA polymorphisms are involved in resistance to malaria [MIM:611162]. |
| Miscellaneous: | |
Involved in several unequal homologous recombinations or gene conversion events, predominantly with GYPB and more rarely with GYPE. The resulting fusion proteins are observed in different phenotypes and encode low incidence bloodgroup antigens. |
| Similarity: | |
Belongs to the glycophorin A family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA52624.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.