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UniProt functional annotation for Q99P68 | ||
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| UniProt code: Q99P68. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. {ECO:0000250, ECO:0000269|PubMed:19419300}. |
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| Subunit: | |
Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6. {ECO:0000250}. |
| Subcellular location: | |
Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Disruption phenotype: | |
Mice were resistant to mechanical unloading- induced bone loss. {ECO:0000269|PubMed:19419300}. |
| Similarity: | |
Belongs to the sclerostin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.