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UniProt functional annotation for Q96PM5 | ||
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| UniProt code: Q96PM5. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21791603, ECO:0000269|PubMed:21994467}. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; |
| Pathway: | |
Protein modification; protein ubiquitination. |
| Subunit: | |
Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1. {ECO:0000269|PubMed:14701804, ECO:0000269|PubMed:15781263, ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:17950244, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087}. |
| Subcellular location: | |
Nucleus. Nucleus speckle. Cytoplasm. |
| Induction: | |
Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase. |
| Ptm: | |
Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability. {ECO:0000269|PubMed:14701804, ECO:0000269|PubMed:19483087}. |
| Miscellaneous: | |
[Isoform 4]: No ubiquitin protein ligase activity. Down- regulated in hepatocellular carcinoma. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 7]: Gene prediction based on partial mRNA data. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAD92309.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.