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UniProt functional annotation for P07998 | ||
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| UniProt code: P07998. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA. {ECO:0000269|PubMed:17350650}. |
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| Catalytic activity: | |
Reaction=An (RNA) containing cytidine + H(2)O = an (RNA)-3'-cytidine- 3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).; EC=4.6.1.18; |
| Catalytic activity: | |
Reaction=An (RNA) containing uridine + H(2)O = an (RNA)-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).; EC=4.6.1.18; |
| Subunit: | |
Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein. {ECO:0000269|PubMed:17350650}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion). |
| Ptm: | |
N-linked glycans are of complex type. {ECO:0000269|PubMed:3202829}. |
| Similarity: | |
Belongs to the pancreatic ribonuclease family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.