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UniProt functional annotation for Q9Y3M8 | ||
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| UniProt code: Q9Y3M8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
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| Subunit: | |
Homodimer. Interacts with TAX1BP1. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:17380510}. |
| Subcellular location: | |
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet. |
| Tissue specificity: | |
Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. {ECO:0000269|PubMed:12531887, ECO:0000269|PubMed:14697242}. |
Annotations taken from UniProtKB at the EBI.