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UniProt functional annotation for Q20595 | ||
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| UniProt code: Q20595. |
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| Organism: | |
Caenorhabditis elegans. |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. |
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| Function: | |
Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. {ECO:0000269|PubMed:18005989, ECO:0000269|PubMed:19164523}. |
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| Subunit: | |
Homodimer. {ECO:0000269|PubMed:17174978, ECO:0000269|PubMed:18005989}. |
| Domain: | |
The THAP-type zinc finger mediates DNA-binding but is not required for repression of gene expression. {ECO:0000269|PubMed:17174978, ECO:0000269|PubMed:18005989}. |
| Disruption phenotype: | |
Adult life span extension and increased resistance to oxidative and heat stress but not to DNA damage, starvation or pathogen stress. {ECO:0000269|PubMed:19164523}. |
| Similarity: | |
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. {ECO:0000255}. |
Annotations taken from UniProtKB at the EBI.