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UniProt functional annotation for P86294 | ||
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| UniProt code: P86294. |
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| Organism: | |
Plasmodium falciparum (isolate HB3). |
| Taxonomy: | |
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania). |
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| Function: | |
Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers. {ECO:0000269|PubMed:19000816}. |
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| Subunit: | |
Binds actin. {ECO:0000269|PubMed:19000816}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P07274}. |
| Domain: | |
The actin binding residues are poorly conserved between Plasmodium and other organisms. The Plasmodium-specific profilin mini- domain may have a role in binding to membrane phospholipids. |
| Similarity: | |
Belongs to the profilin family. {ECO:0000255}. |
Annotations taken from UniProtKB at the EBI.