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PDBsum entry 2jb8
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protein ligands metals links
Oxidoreductase PDB id
2jb8

 

 

 

 

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Contents
Protein chain
273 a.a. *
Ligands
HKV
Metals
_FE
Waters ×217
* Residue conservation analysis
PDB id:
2jb8
Name: Oxidoreductase
Title: Deacetoxycephalosporin c synthase complexed with 5-hydroxy-4-keto valeric acid
Structure: Deacetoxycephalosporin c synthetase. Chain: a. Synonym: daocs, expandase, deacetoxycephalosporin c synthase. Engineered: yes
Source: Streptomyces clavuligerus. Organism_taxid: 1901. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.53Å     R-factor:   0.212     R-free:   0.249
Authors: G.Cicero,C.Carbonera,K.Valegard,J.Hajdu,I.Andersson,G.Ranghino
Key ref: G.Cicero et al. Study of the oxidative half-Reaction catalysed by a non-Heme ferrous catalytic centre by means of structural and computational methodologies. To be published, .
Date:
05-Dec-06     Release date:   05-Feb-08    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P18548  (CEFE_STRCL) -  Deacetoxycephalosporin C synthase from Streptomyces clavuligerus
Seq:
Struc: 		311 a.a.
273 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.14.20.1  - deacetoxycephalosporin-C synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway: 		Penicillin N and Deacetoxycephalosporin C Biosynthesis
      Reaction: penicillin N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O
penicillin N
Bound ligand (Het Group name = HKV)
matches with 90.00% similarity 		+ 2-oxoglutarate
 + O2
 = deacetoxycephalosporin C
 + succinate
 + CO2
 + H2O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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