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UniProt functional annotation for P17169 | ||
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| UniProt code: P17169. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. |
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| Catalytic activity: | |
Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6- phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16; |
| Subunit: | |
Homodimer. |
| Subcellular location: | |
Cytoplasm. |
| Induction: | |
Post-transcriptionally regulated by the GlmY/GlmZ sRNA regulatory cascade. The sRNA GlmZ, together with Hfq, directly activates glmS mRNA translation through base-pairing. A second sRNA, GlmY, positively regulates glmS indirectly, by sequestering the adapter protein RapZ and protecting GlmZ from RNA cleavage. {ECO:0000269|PubMed:18334534, ECO:0000269|PubMed:18351803, ECO:0000269|PubMed:23475961}. |
Annotations taken from UniProtKB at the EBI.