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UniProt functional annotation for Q06339 | ||
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| UniProt code: Q06339. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with TFC3 in DNA binding. {ECO:0000269|PubMed:2651441, ECO:0000269|PubMed:9418847}. |
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| Subunit: | |
Heterodimer with TFC8. Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker. Interacts with TFC1, TFC3, TFC4 and directly with TFC8. {ECO:0000269|PubMed:12533520, ECO:0000269|PubMed:16115780, ECO:0000269|PubMed:17052456, ECO:0000269|PubMed:7688737, ECO:0000269|PubMed:9418847}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:14562095}. |
| Miscellaneous: | |
Present with 1130 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
Annotations taken from UniProtKB at the EBI.