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UniProt functional annotation for P07658 | ||
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| UniProt code: P07658. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors. |
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| Catalytic activity: | |
Reaction=A + formate + H(+) = AH2 + CO2; Xref=Rhea:RHEA:27290, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:16526, ChEBI:CHEBI:17499; EC=1.17.98.4; Evidence={ECO:0000269|PubMed:16830149, ECO:0000269|PubMed:9036855, ECO:0000269|PubMed:9521673}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; |
| Cofactor: | |
Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI:CHEBI:60539; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo- bis-MGD) cofactor per subunit.; |
| Activity regulation: | |
Inhibited by aerobic conditions. {ECO:0000269|PubMed:8626495, ECO:0000269|PubMed:9521673}. |
| Subunit: | |
Consists of two separable enzymatic activities: a formate dehydrogenase component (FDH-H) and hydrogenase-3. {ECO:0000269|PubMed:16830149, ECO:0000269|PubMed:9036855}. |
| Induction: | |
By formate. Repressed by oxygen, nitrate, nitrite, and other electron acceptors. |
| Similarity: | |
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.