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UniProt functional annotation for P0CD76 | ||
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| UniProt code: P0CD76. |
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| Organism: | |
Chlamydia trachomatis (strain D/UW-3/Cx). |
| Taxonomy: | |
Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia/Chlamydophila group; Chlamydia. |
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| Function: | |
Catalyzes the N-acylation of UDP-3-O-myristoylglucosamine using 3-hydroxyarachidoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (Probable). {ECO:0000305|PubMed:10358025}. |
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| Catalytic activity: | |
Reaction=a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine = a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP]; Xref=Rhea:RHEA:53836, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:64479, ChEBI:CHEBI:78827, ChEBI:CHEBI:137740, ChEBI:CHEBI:137748; |
| Pathway: | |
Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. |
| Subunit: | |
Homotrimer. {ECO:0000269|PubMed:17360522}. |
| Similarity: | |
Belongs to the transferase hexapeptide repeat family. LpxD subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.