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UniProt functional annotation for Q9HWH2 | ||
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| UniProt code: Q9HWH2. |
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| Organism: | |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. |
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| Function: | |
Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Converts phenazine-1-carboxylate (PCA) to 5-methylphenazine-1-carboxylate (5- methyl-PCA). {ECO:0000269|PubMed:17253782}. |
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| Catalytic activity: | |
Reaction=phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl- phenazine-1-carboxylate + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:49112, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:62221, ChEBI:CHEBI:62248; EC=2.1.1.327; Evidence={ECO:0000269|PubMed:17253782}; |
| Activity regulation: | |
In vitro, requires PhzS for activity. {ECO:0000269|PubMed:17253782}. |
| Pathway: | |
Secondary metabolite biosynthesis; pyocyanine biosynthesis. {ECO:0000269|PubMed:17253782}. |
| Subunit: | |
Homodimer in solution (PubMed:16946471, PubMed:17253782). Probably interacts transiently with PhzS (PubMed:17253782). {ECO:0000269|PubMed:16946471, ECO:0000269|PubMed:17253782}. |
| Domain: | |
Contains an N-terminal dimerization domain. The C-terminal region contains the S-adenosyl-L-methionine binding site. {ECO:0000269|PubMed:17253782}. |
| Similarity: | |
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU01020}. |
Annotations taken from UniProtKB at the EBI.