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UniProt functional annotation for P41007 | ||
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| UniProt code: P41007. |
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| Organism: | |
Bacillus caldolyticus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus; Geobacillus thermoleovorans group. |
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| Function: | |
Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable). {ECO:0000305}. |
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| Function: | |
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. |
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| Catalytic activity: | |
Reaction=diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil; Xref=Rhea:RHEA:13017, ChEBI:CHEBI:17568, ChEBI:CHEBI:33019, ChEBI:CHEBI:57865, ChEBI:CHEBI:58017; EC=2.4.2.9; |
| Subunit: | |
Homodimer and homohexamer; in equilibrium. {ECO:0000250}. |
| Similarity: | |
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.