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UniProt functional annotation for Q16875 | ||
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| UniProt code: Q16875. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Synthesis and degradation of fructose 2,6-bisphosphate. |
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| Catalytic activity: | |
Reaction=beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate; Xref=Rhea:RHEA:17289, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579; EC=3.1.3.46; |
| Catalytic activity: | |
Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6- bisphosphate + H(+); Xref=Rhea:RHEA:15653, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579, ChEBI:CHEBI:456216; EC=2.7.1.105; |
| Tissue specificity: | |
Ubiquitous. |
| Ptm: | |
Phosphorylation by AMPK stimulates activity. {ECO:0000269|PubMed:12065600}. |
| Similarity: | |
In the C-terminal section; belongs to the phosphoglycerate mutase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.