UniProt functional annotation for Q6RHR9



	UniProt functional annotation for Q6RHR9

UniProt code: Q6RHR9.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface. {ECO:0000269|PubMed:15317815}.

Subunit: Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of ADGRB1. Interacts via its WW domains with DRPLA (By similarity). Interacts with ESAM, LRP2 and CXADR (PubMed:15383320, PubMed:11274227, PubMed:15304526). Isoform 2 interacts with CTNNB1 (PubMed:10772923). Interacts through its PDZ 1 domain with NET1 (PubMed:11350080). Interacts with ASIC3 and AMOT (By similarity) (PubMed:15317815). Interacts with FCHSD2 (By similarity). Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity). Interacts with DDN. May interact (via PDZ domain) with RAPGEF2 (By similarity). Interacts with DLL1 (PubMed:15509766). Interacts with KCNJ10 and possibly with KCNJ10/KCNJ16 heterodimer; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney tubular cells (By similarity). Interacts with PRRG4 (via cytoplasmic domain) (By similarity). {ECO:0000250|UniProtKB:Q4L1J4, ECO:0000250|UniProtKB:Q96QZ7, ECO:0000269|PubMed:10772923, ECO:0000269|PubMed:11274227, ECO:0000269|PubMed:11350080, ECO:0000269|PubMed:15304526, ECO:0000269|PubMed:15317815, ECO:0000269|PubMed:15383320, ECO:0000269|PubMed:15509766}.

Subcellular location: [Isoform 2]: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000250}. Note=Localizes to epithelial cells tight junctions. {ECO:0000250}.

Subcellular location: [Isoform 3]: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.

Subcellular location: [Isoform 1]: Nucleus {ECO:0000305}.

Tissue specificity: Widely expressed, including kidney glomeruli. {ECO:0000269|PubMed:11274227, ECO:0000269|PubMed:9395497}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface. {ECO:0000269\|PubMed:15317815}.


Subunit:		Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of ADGRB1. Interacts via its WW domains with DRPLA (By similarity). Interacts with ESAM, LRP2 and CXADR (PubMed:15383320, PubMed:11274227, PubMed:15304526). Isoform 2 interacts with CTNNB1 (PubMed:10772923). Interacts through its PDZ 1 domain with NET1 (PubMed:11350080). Interacts with ASIC3 and AMOT (By similarity) (PubMed:15317815). Interacts with FCHSD2 (By similarity). Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity). Interacts with DDN. May interact (via PDZ domain) with RAPGEF2 (By similarity). Interacts with DLL1 (PubMed:15509766). Interacts with KCNJ10 and possibly with KCNJ10/KCNJ16 heterodimer; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney tubular cells (By similarity). Interacts with PRRG4 (via cytoplasmic domain) (By similarity). {ECO:0000250\|UniProtKB:Q4L1J4, ECO:0000250\|UniProtKB:Q96QZ7, ECO:0000269\|PubMed:10772923, ECO:0000269\|PubMed:11274227, ECO:0000269\|PubMed:11350080, ECO:0000269\|PubMed:15304526, ECO:0000269\|PubMed:15317815, ECO:0000269\|PubMed:15383320, ECO:0000269\|PubMed:15509766}.
Subcellular location:		[Isoform 2]: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000250}. Note=Localizes to epithelial cells tight junctions. {ECO:0000250}.
Subcellular location:		[Isoform 3]: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Subcellular location:		[Isoform 1]: Nucleus {ECO:0000305}.
Tissue specificity:		Widely expressed, including kidney glomeruli. {ECO:0000269\|PubMed:11274227, ECO:0000269\|PubMed:9395497}.