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UniProt functional annotation for P52597 | ||
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| UniProt code: P52597. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
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| Subunit: | |
Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1. {ECO:0000269|PubMed:11054566, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16885237, ECO:0000269|PubMed:17932509}. |
| Subcellular location: | |
Nucleus, nucleoplasm. |
| Tissue specificity: | |
Expressed ubiquitously. |
| Domain: | |
The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA. |
| Ptm: | |
Sumoylated. {ECO:0000269|PubMed:15161980}. |
Annotations taken from UniProtKB at the EBI.