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UniProt functional annotation for O95715 | ||
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| UniProt code: O95715. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. {ECO:0000269|PubMed:10049774, ECO:0000269|PubMed:10946286}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes. {ECO:0000269|PubMed:10049774, ECO:0000269|PubMed:10854217, ECO:0000269|PubMed:10946286}. |
| Induction: | |
Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS). {ECO:0000269|PubMed:10854217}. |
| Domain: | |
The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16987528}. |
| Ptm: | |
Ubiquitinated, followed by degradation by the proteasome. {ECO:0000269|PubMed:16987528}. |
| Similarity: | |
Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAD38944.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.