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UniProt functional annotation for Q16663 | ||
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| UniProt code: Q16663. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. {ECO:0000269|PubMed:15905581}. |
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| Subunit: | |
Monomer. {ECO:0000269|PubMed:10320325}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. {ECO:0000269|PubMed:15905581, ECO:0000269|PubMed:9558365}. |
| Similarity: | |
Belongs to the intercrine beta (chemokine CC) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.