UniProt functional annotation for P0CS82



	UniProt functional annotation for P0CS82

UniProt code: P0CS82.

Organism: Saccharomyces cerevisiae (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Regulation of oxygen dependent gene expression. It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c. In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes. Binds to the sequence 5'-CGGNNNTNNCGG-3'. Is non- functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives. {ECO:0000269|PubMed:10541856, ECO:0000269|PubMed:11689685, ECO:0000269|PubMed:2851658, ECO:0000269|PubMed:9027731}.

Subunit: Binds DNA as a homodimer. Interacts with SRO9 and YDJ1. In the absence of heme, binds to at least four cellular proteins, including YDJ1 and SRO9, forming a high-molecular-weight complex (HMC) which results in repression of its activity and dictates its DNA-binding specificity. {ECO:0000269|PubMed:11689685, ECO:0000269|PubMed:8182072, ECO:0000269|PubMed:9886294}.

Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:8182072}.

Miscellaneous: Heme is an effector molecule for CYP1/HAP1. The HRM repeat region mediates heme induction by masking the DNA-binding domain in the absence of inducer.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Regulation of oxygen dependent gene expression. It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c. In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes. Binds to the sequence 5'-CGGNNNTNNCGG-3'. Is non- functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives. {ECO:0000269\|PubMed:10541856, ECO:0000269\|PubMed:11689685, ECO:0000269\|PubMed:2851658, ECO:0000269\|PubMed:9027731}.


Subunit:		Binds DNA as a homodimer. Interacts with SRO9 and YDJ1. In the absence of heme, binds to at least four cellular proteins, including YDJ1 and SRO9, forming a high-molecular-weight complex (HMC) which results in repression of its activity and dictates its DNA-binding specificity. {ECO:0000269\|PubMed:11689685, ECO:0000269\|PubMed:8182072, ECO:0000269\|PubMed:9886294}.
Subcellular location:		Nucleus {ECO:0000255\|PROSITE-ProRule:PRU00227, ECO:0000269\|PubMed:8182072}.
Miscellaneous:		Heme is an effector molecule for CYP1/HAP1. The HRM repeat region mediates heme induction by masking the DNA-binding domain in the absence of inducer.