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UniProt functional annotation for Q9WYW0 | ||
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| UniProt code: Q9WYW0. |
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| Organism: | |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8). |
| Taxonomy: | |
Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga. |
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| Function: | |
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Has also depropionylation activity in vitro. Also able to ADP- ribosylate peptide substrates with Arg or Lys in the +2 position. The role of this function in vivo is not clear. {ECO:0000255|HAMAP- Rule:MF_01968, ECO:0000269|PubMed:16905097, ECO:0000269|PubMed:17684016, ECO:0000269|PubMed:19801667}. |
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| Catalytic activity: | |
Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence={ECO:0000255|HAMAP-Rule:MF_01968, ECO:0000269|PubMed:16905097}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|HAMAP-Rule:MF_01968, ECO:0000269|PubMed:15780941, ECO:0000269|PubMed:16768447, ECO:0000269|PubMed:16905097}; Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01968, ECO:0000269|PubMed:15780941, ECO:0000269|PubMed:16768447, ECO:0000269|PubMed:16905097}; |
| Activity regulation: | |
Non-competitively inhibited by nicotinamide but not by nicotinic acid. {ECO:0000269|PubMed:15780941}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01968}. |
| Similarity: | |
Belongs to the sirtuin family. Class U subfamily. {ECO:0000255|HAMAP-Rule:MF_01968}. |
Annotations taken from UniProtKB at the EBI.