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PDBsum entry 2h2k
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Metal binding protein
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PDB id
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2h2k
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References listed in PDB file
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Key reference
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Title
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Crystal structure study on human s100a13 at 2.0 a resolution.
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Authors
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M.Li,
P.F.Zhang,
X.W.Pan,
W.R.Chang.
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Ref.
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Biochem Biophys Res Commun, 2007,
356,
616-621.
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PubMed id
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Abstract
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The S100 protein family is the largest group of calcium-binding protein
families, which consists of at least 25 members. S100A13, which is widely
expressed in a variety of tissues, is a unique member of the S100 protein
family. Previous reports showed that S100A13 might be involved in the
stress-induced release of some signal peptide-less proteins (such as FGF-1 and
IL-1alpha) and also associated with inflammatory functions. It was also reported
that S100A13 is a new angiogenesis marker. Here we report the crystal structure
of the Ca(2+)-bound form of S100A13 at 2.0 A resolution. S100A13 is a homodimer
with four EF-hand motifs in an asymmetric unit, displaying a folding pattern
similar to other S100 members. However, S100A13 has the unique structural
feature with all alpha-helices being amphiphilic, which was not found in other
members of S100s. We propose that this characteristic structure of S100A13 might
be related to its ability to mediate the release of FGF-1 and IL-1alpha.
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