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UniProt functional annotation for P48443 | ||
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| UniProt code: P48443. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). {ECO:0000250}. |
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| Subunit: | |
Homodimer (By similarity). Heterodimer with a RAR molecule (PubMed:28167758). Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:28167758). Interacts with RARA (PubMed:28167758). {ECO:0000250|UniProtKB:P19793, ECO:0000269|PubMed:28167758}. |
| Subcellular location: | |
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:28167758}. |
| Tissue specificity: | |
Expressed in aortic endothelial cells (at protein level). {ECO:0000269|PubMed:28167758}. |
| Domain: | |
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. {ECO:0000250}. |
| Ptm: | |
Acetylated by EP300. {ECO:0000269|PubMed:17761950}. |
| Similarity: | |
Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.