UniProt functional annotation for P18010



	UniProt functional annotation for P18010

UniProt code: P18010.

Organism: Shigella flexneri.

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella.

Function: Rapidly associates with the first 265 amino acids of vinculin after bacteria-cell contact. This interaction is critical for efficient Shigella uptake. IpaA acts as a potent activator of vinculin and increase its ability to interact with F-actin. The complex IpaA- vinculin induces F-actin depolymerization along with the occasional formation of actin filament bundles. {ECO:0000269|PubMed:10545097, ECO:0000269|PubMed:9184218}.

Subunit: The association of the vinculin-IpaA complex with actin occurs via the F-actin binding domain located on the tail of vinculin.

Subcellular location: Secreted. Note=Secreted through the specialized type-III secretion system Mxi/Spa from the bacterium through the cell cytosol.

Induction: Synthesis of this immunogen is repressed at 30 degrees Celsius and restored at 37 degrees Celsius.

Disruption phenotype: Cells are still able to induce low levels of internalization, but are impaired in their ability to enter epithelial cells. {ECO:0000269|PubMed:9184218}.

Similarity: Belongs to the SipA/IpaA family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Shigella flexneri.
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella.



Function:		Rapidly associates with the first 265 amino acids of vinculin after bacteria-cell contact. This interaction is critical for efficient Shigella uptake. IpaA acts as a potent activator of vinculin and increase its ability to interact with F-actin. The complex IpaA- vinculin induces F-actin depolymerization along with the occasional formation of actin filament bundles. {ECO:0000269\|PubMed:10545097, ECO:0000269\|PubMed:9184218}.


Subunit:		The association of the vinculin-IpaA complex with actin occurs via the F-actin binding domain located on the tail of vinculin.
Subcellular location:		Secreted. Note=Secreted through the specialized type-III secretion system Mxi/Spa from the bacterium through the cell cytosol.
Induction:		Synthesis of this immunogen is repressed at 30 degrees Celsius and restored at 37 degrees Celsius.
Disruption phenotype:		Cells are still able to induce low levels of internalization, but are impaired in their ability to enter epithelial cells. {ECO:0000269\|PubMed:9184218}.
Similarity:		Belongs to the SipA/IpaA family. {ECO:0000305}.