The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the
thermophile Methanococcus jannaschii has been determined using multinuclear
multidimensional NMR spectroscopy. The structure is similar to homologs from
other organisms that have been determined by crystallography, with some
variation in the N-terminal domain. The C-terminal domain is more highly
conserved in both sequence and structure. Regions of the protein show
broadening, reflecting conformational flexibility that is likely related to
function.
