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UniProt functional annotation for Q01852 | ||
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| UniProt code: Q01852. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source. {ECO:0000269|PubMed:18426906, ECO:0000269|PubMed:26714107}. |
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| Subunit: | |
Component of the PAM complex, at least composed of SSC1 (mtHsp70), MGE1, TIM44, PAM16/TIM16, PAM17 and PAM18/TIM14. Forms part of the receptor complex that consists of at least 3 different proteins (TIM17, TIM23, TIM44). {ECO:0000269|PubMed:16107694, ECO:0000269|PubMed:18426906, ECO:0000269|PubMed:26714107}. |
| Subcellular location: | |
Mitochondrion inner membrane {ECO:0000269|PubMed:18426906}; Peripheral membrane protein {ECO:0000269|PubMed:18426906}. |
| Similarity: | |
Belongs to the Tim44 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.