|
|
||
|
|
|
|
|
UniProt functional annotation for Q04477 | ||
|
|
|
|
|
|
||
| UniProt code: Q04477. |
|
||
| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
|
||
|
||
| Function: | |
Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity. {ECO:0000269|PubMed:11266451, ECO:0000269|PubMed:11952896, ECO:0000269|PubMed:12514103}. |
|
||
| Subunit: | |
Component of the NDC80 complex, which consists of TID3/NDC80, NUF2, SPC24 and SPC25. The NDC80 complex is formed by two subcomplexes, TID3/NDC80-NUF2 and SPC24-SPC25, which are joined end-to-end through their coiled-coil domains. It has a rod-like structure with a length of 570 Angstroms and globular domains at either end. The TID3/NDC80-NUF2 globular domains are probably directed to microtubules, the SPC24-SPC25 globular domains to the centromere. Can also interact with MPS2. {ECO:0000269|PubMed:11266451, ECO:0000269|PubMed:15371542}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:11179222, ECO:0000269|PubMed:11266451, ECO:0000269|PubMed:11952896}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11179222, ECO:0000269|PubMed:11266451, ECO:0000269|PubMed:11952896}. Note=Associated with kinetochores. {ECO:0000269|PubMed:11179222, ECO:0000269|PubMed:11266451, ECO:0000269|PubMed:11952896}. |
| Miscellaneous: | |
Present with 1750 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the SPC24 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.