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UniProt functional annotation for Q92871 | ||
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| UniProt code: Q92871. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}. |
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| Catalytic activity: | |
Reaction=alpha-D-mannose 1-phosphate = D-mannose 6-phosphate; Xref=Rhea:RHEA:11140, ChEBI:CHEBI:58409, ChEBI:CHEBI:58735; EC=5.4.2.8; Evidence={ECO:0000269|PubMed:16540464}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:16540464}; |
| Activity regulation: | |
IMP, a metabolite whose concentration is elevated in anoxia, inhibits phosphomannomutase and phosphoglucomutase activities and strongly enhances glucose-1,6-bisphosphatase activity. {ECO:0000250|UniProtKB:O35621}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=54 uM for alpha-D-mannose 1-phosphate {ECO:0000269|PubMed:16540464}; KM=7.5 uM for alpha-D-glucose 1-phosphate {ECO:0000269|PubMed:16540464}; |
| Pathway: | |
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:16540464}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250|UniProtKB:O35621}. |
| Tissue specificity: | |
Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle. |
| Similarity: | |
Belongs to the eukaryotic PMM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.