UniProt functional annotation for Q2RSB2

UniProt code: Q2RSB2.

Organism: Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1).
Taxonomy: Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales; Rhodospirillaceae; Rhodospirillum.
 
Function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. {ECO:0000250|UniProtKB:P07001}.
 
Catalytic activity: Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+); Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1; Evidence={ECO:0000269|PubMed:12564924, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:16533815, ECO:0000269|PubMed:17323922};
Subunit: Heterotrimer of two alpha chains and a beta (PntB) chain; in Rhodospirillum, the alpha chain is made of two subunits (PntAA and PntAB) and forms a dimer. {ECO:0000269|PubMed:10997900, ECO:0000269|PubMed:11250201, ECO:0000269|PubMed:12564924, ECO:0000269|PubMed:12791694, ECO:0000269|PubMed:15670609}.
Similarity: Belongs to the AlaDH/PNT family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.