PDBsum entry 2for

Transferase

PDB id: 2for

Contents

Protein chains

283 a.a. *

Ligands

PO4 ×6

IPR

PO4-IPR

Waters ×354

* Residue conservation analysis

PDB id:

2for

Name:

Transferase

Title:

Crystal structure of the shigella flexneri farnesyl pyrophosphate synthase complex with an isopentenyl pyrophosphate

Structure:

Geranyltranstransferase. Chain: a, b. Synonym: farnesyl-diphosphate synthase. Fpp synthase. Engineered: yes

Source:

Shigella flexneri. Organism_taxid: 623. Strain: 301. Gene: aap15892. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Dimer (from PQS)

Resolution:

2.00Å R-factor: 0.184 R-free: 0.233

Authors:

G.Minasov,J.S.Brunzelle,L.Shuvalova,F.R.Collart,A.Joachimiak, W.F.Anderson,Midwest Center For Structural Genomics (Mcsg)

Key ref:

G.Minasov et al. Crystal structure of the shigella flexneri farnesyl pyrophosphate synthase complex with an isopentenyl pyrophosphate. To be published, .

Date:

13-Jan-06 Release date: 31-Jan-06

Protein chains

A0A0H2UXE9  (A0A0H2UXE9_SHIFL) -  Geranyltranstransferase (Farnesyldiphosphate synthase) from Shigella flexneri

Seq: 299 a.a.

Struc: 283 a.a.

Enzyme reactions

• Enzyme class: E.C.2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase.
• Pathway: Terpenoid biosynthesis
• Reaction: isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate

isopentenyl diphosphate + (2E)-geranyl diphosphate (Bound ligand (Het Group name = IPR) corresponds exactly) = (2E,6E)-farnesyl diphosphate + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site