UniProt functional annotation for P14585



	UniProt functional annotation for P14585

UniProt code: P14585.

Organism: Caenorhabditis elegans.

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.

Function: Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12/Notch encodes a membrane- bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling (PubMed:27661254). {ECO:0000269|PubMed:27661254, ECO:0000269|PubMed:3000611, ECO:0000269|PubMed:3419531}.

Subunit: Interacts with sel-10 (PubMed:9389650). Component of a complex consisting of at least lag-1, lin-12/Notch and lag-3 (PubMed:16530045, PubMed:18381292). Probably facilitates ordered assembly of the ternary complex via allosteric interactions of the RBP-j associated molecule (RAM) domain with lag-1 (PubMed:16530045, PubMed:18381292). {ECO:0000269|PubMed:16530045, ECO:0000269|PubMed:18381292, ECO:0000269|PubMed:9389650}.

Subcellular location: Apical cell membrane {ECO:0000269|PubMed:32053105}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes to the apical cell membrane of vulval precursor cells. {ECO:0000269|PubMed:32053105}.

Disruption phenotype: RNAi-mediated knockdown in cells of the pi uterine cell lineage results in impaired basement membrane mobility. {ECO:0000269|PubMed:27661254}.

Annotations taken from UniProtKB at the EBI.


Organism:		Caenorhabditis elegans.
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.



Function:		Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12/Notch encodes a membrane- bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling (PubMed:27661254). {ECO:0000269\|PubMed:27661254, ECO:0000269\|PubMed:3000611, ECO:0000269\|PubMed:3419531}.


Subunit:		Interacts with sel-10 (PubMed:9389650). Component of a complex consisting of at least lag-1, lin-12/Notch and lag-3 (PubMed:16530045, PubMed:18381292). Probably facilitates ordered assembly of the ternary complex via allosteric interactions of the RBP-j associated molecule (RAM) domain with lag-1 (PubMed:16530045, PubMed:18381292). {ECO:0000269\|PubMed:16530045, ECO:0000269\|PubMed:18381292, ECO:0000269\|PubMed:9389650}.
Subcellular location:		Apical cell membrane {ECO:0000269\|PubMed:32053105}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes to the apical cell membrane of vulval precursor cells. {ECO:0000269\|PubMed:32053105}.
Disruption phenotype:		RNAi-mediated knockdown in cells of the pi uterine cell lineage results in impaired basement membrane mobility. {ECO:0000269\|PubMed:27661254}.