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PDBsum entry 2fgo
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Electron transport
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PDB id
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2fgo
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References listed in PDB file
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Key reference
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Title
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The structure of the 2[4fe-4s] ferredoxin from pseudomonas aeruginosa at 1.32-A resolution: comparison with other high-Resolution structures of ferredoxins and contributing structural features to reduction potential values.
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Authors
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P.Giastas,
N.Pinotsis,
G.Efthymiou,
M.Wilmanns,
P.Kyritsis,
J.M.Moulis,
I.M.Mavridis.
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Ref.
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J Biol Inorg Chem, 2006,
11,
445-458.
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PubMed id
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Abstract
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The structure of the 2[4Fe-4S] ferredoxin (PaFd) from Pseudomonas aeruginosa,
which belongs to the Allochromatium vinosum (Alvin) subfamily, has been
determined by X-ray crystallography at 1.32-A resolution, which is the highest
up to now for a member of this subfamily of Fds. The main structural features of
PaFd are similar to those of AlvinFd. However, the significantly higher
resolution of the PaFd structure makes possible a reliable comparison with
available high-resolution structures of [4Fe-4S]-containing Fds, in an effort to
rationalize the unusual electrochemical properties of Alvin-like Fds. Three
major factors contributing to the reduction potential values of [4Fe-4S]2+/+
clusters of Fds, namely, the surface accessibility of the clusters, the N-H...S
hydrogen-bonding network, and the volume of the cavities hosting the clusters,
are extensively discussed. The volume of the cavities is introduced in the
present work for the first time, and can in part explain the very negative
potential of cluster I of Alvin-like Fds.
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