PDBsum entry 2ff5

Transferase

PDB id: 2ff5

Contents

Protein chain

807 a.a. *

Ligands

PLP

H53

Waters ×235

* Residue conservation analysis

PDB id:

2ff5

Name:

Transferase

Title:

Synthesis of c-d-glycopyranosyl-hydroquinones and-benzoquinones. Inhibition of ptp1b. Inhibition of and binding to glycogen phosphorylase in the crystal

Structure:

Glycogen phosphorylase, muscle form. Chain: a. Synonym: myophosphorylase. Other_details: pyridoxal-5'-phosphate bound

Source:

Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle

Resolution:

2.03Å R-factor: 0.187 R-free: 0.212

Authors:

E.D.Chrysina,M.N.Kosmopoulou,D.D.Leonidas,N.G.Oikonomakos

Key ref:

L.He et al. (2007). In the search of glycogen phosphorylase inhibitors: synthesis of c-D-Glycopyranosylbenzo(hydro)quinones inhibition of and binding to glycogen phosphorylase in the crystal. Eur j org chem, 4, 596-606.

Date:

19-Dec-05 Release date: 19-Dec-06

Protein chain

P00489  (PYGM_RABIT) -  Glycogen phosphorylase, muscle form from Oryctolagus cuniculus

Seq: 843 a.a.

Struc: 807 a.a.

Enzyme reactions

• Enzyme class: E.C.2.4.1.1 - glycogen phosphorylase.
• Pathway: Glycogen
• Reaction: [(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate

[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate (Bound ligand (Het Group name = PLP) matches with 63.16% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site