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PDBsum entry 2fe6
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Oxidoreductase
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PDB id
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2fe6
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References listed in PDB file
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Key reference
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Title
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The status of high-Valent metal oxo complexes in the p450 cytochromes.
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Authors
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T.M.Makris,
K.Von koenig,
I.Schlichting,
S.G.Sligar.
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Ref.
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J Inorg Biochem, 2006,
100,
507-518.
[DOI no: ]
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PubMed id
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Abstract
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The oxidative prowess of the P450 cytochromes in physiological reactions is
attributed to the production of a high-valent iron-oxo complex, or Compound I
intermediate, in the reaction cycle. Despite many years of study, however, the
full electronic description of this fleeting intermediate still remains an
active area of study. In this manuscript, the current status of the isolation
and characterization of the P450 oxo-Fe(IV) is examined and compared to
analogous states in related heme enzymes. In addition, the utilization of
cofactor exchange to stabilize high-valent oxo-states in the P450 is addressed.
Structural and spectroscopic studies on manganese reconstituted P450, and its
corresponding oxo-complex, are presented.
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