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UniProt functional annotation for P71086 | ||
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| UniProt code: P71086. |
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| Organism: | |
Bacillus subtilis (strain 168). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
Hydrogen and organic peroxide sensor. Represses the expression of a regulon of peroxide-inducible genes such as katA, ahpC, ahpF, the heme biosynthesis operon (hemAXCDBL), fur, perR, zosA and mrgA. |
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| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Mn(2+) or Fe(2+) ion per subunit.; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:16925555}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Ptm: | |
Possibly oxidized on a cysteine residue; the Cys-SOH formed in response to oxidative signaling may rapidly react with a Cys-SH to form a disulfide bond, leading to the loss of metal ion and inactivation of repressor function. Oxidized PerR can be further reduced by thiol reductants and repressor activity restored. |
| Similarity: | |
Belongs to the Fur family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.