UniProt functional annotation for Q03405



	UniProt functional annotation for Q03405

UniProt code: Q03405.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Subunit: Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane. Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (PubMed:14764453, PubMed:23486467). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (PubMed:15053742). {ECO:0000269|PubMed:10636902, ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:14764453, ECO:0000269|PubMed:15053742, ECO:0000269|PubMed:15861141, ECO:0000269|PubMed:16456079, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:22285761, ECO:0000269|PubMed:23486467, ECO:0000305}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12376466}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin- dependent manner. {ECO:0000269|PubMed:12376466}.

Subcellular location: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P49616}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P49616}.

Subcellular location: [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}.

Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.


Subunit:		Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane. Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (PubMed:14764453, PubMed:23486467). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (PubMed:15053742). {ECO:0000269\|PubMed:10636902, ECO:0000269\|PubMed:12376466, ECO:0000269\|PubMed:14764453, ECO:0000269\|PubMed:15053742, ECO:0000269\|PubMed:15861141, ECO:0000269\|PubMed:16456079, ECO:0000269\|PubMed:18718938, ECO:0000269\|PubMed:22285761, ECO:0000269\|PubMed:23486467, ECO:0000305}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:12376466}. Cell projection, invadopodium membrane {ECO:0000269\|PubMed:12376466}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin- dependent manner. {ECO:0000269\|PubMed:12376466}.
Subcellular location:		[Isoform 1]: Cell membrane {ECO:0000250\|UniProtKB:P49616}; Lipid-anchor, GPI-anchor {ECO:0000250\|UniProtKB:P49616}.
Subcellular location:		[Isoform 2]: Secreted {ECO:0000250\|UniProtKB:P49616}.
Tissue specificity:		Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.