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PDBsum entry 2f9b
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Hydrolase/blood clotting
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PDB id
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2f9b
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Contents |
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94 a.a.
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254 a.a.
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149 a.a.
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References listed in PDB file
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Key reference
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Title
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Discovery of novel heterocyclic factor viia inhibitors.
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Authors
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R.Rai,
A.Kolesnikov,
P.A.Sprengeler,
S.Torkelson,
T.Ton,
B.A.Katz,
C.Yu,
J.Hendrix,
W.D.Shrader,
R.Stephens,
R.Cabuslay,
E.Sanford,
W.B.Young.
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Ref.
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Bioorg Med Chem Lett, 2006,
16,
2270-2273.
[DOI no: ]
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PubMed id
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Abstract
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Structure-activity relationships and binding mode of novel heterocyclic factor
VIIa inhibitors will be described. In these inhibitors, a highly basic
5-amidinoindole moiety has been successfully replaced with a less basic
5-aminopyrrolo[3,2-b]pyridine scaffold.
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