PDBsum entry 2f0y

Transferase

PDB id: 2f0y

Contents

Protein chains

314 a.a.

395 a.a.

Ligands

FPP

3MN

Metals

_ZN

Waters ×409

References listed in PDB file

Key reference

• Title: Hydantoin derivatives as non-Peptidic inhibitors of ras farnesyl transferase.
• Authors: J.Lee, J.Kim, J.S.Koh, H.H.Chung, K.H.Kim.
• Ref.: Bioorg Med Chem Lett, 2006, 16, 1954-1956.
• PubMed id: 16442288

Note In the PDB file this reference is annotated as "TO BE PUBLISHED". The citation details given above were identified by an automated search of PubMed on title and author names, giving a percentage match of 94%.

Abstract

1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps.