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UniProt functional annotation for P37019 | ||
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| UniProt code: P37019. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. {ECO:0000269|PubMed:12384697, ECO:0000269|PubMed:14985752, ECO:0000269|PubMed:16341087, ECO:0000269|PubMed:16905147, ECO:0000269|PubMed:18678918}. |
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| Subunit: | |
Homodimer. {ECO:0000269|PubMed:18678918}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Induction: | |
By acid-shock conditions. |
| Similarity: | |
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.