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PDBsum entry 2est
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Hydrolase/hydrolase inhibitor
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PDB id
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2est
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crystallographic study of the binding of a trifluoroacetyl dipeptide anilide inhibitor with elastase.
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Authors
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D.L.Hughes,
L.C.Sieker,
J.Bieth,
J.L.Dimicoli.
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Ref.
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J Mol Biol, 1982,
162,
645-658.
[DOI no: ]
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PubMed id
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Abstract
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No abstract given.
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Figure 1.
FIG. 1. Superposition f the inhibitor molecule and some neighbouring residues on the final difference
map (p,- IF,/) or TFAP in the active site region. Contours ar drawn at estimated lrvrls of 0,;5, I.0 and
1.5 I?.
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Figure 3.
FIG. 3. Th active centre region in: (a) native elastase (pH 5.0); (b) tosyl-elastase; and (c) the
TFAl/elastase complex, TFAP.
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The above figures are
reprinted
by permission from Elsevier:
J Mol Biol
(1982,
162,
645-658)
copyright 1982.
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Secondary reference #1
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Title
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The indirect mechanism of action of the trifluoroacetyl peptides on elastase. Enzymatic and 19f nmr studies.
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Authors
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J.L.Dimicoli,
A.Renaud,
J.Bieth.
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Ref.
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Eur J Biochem, 1980,
107,
423-432.
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PubMed id
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Secondary reference #2
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Title
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The atomic structure of crystalline porcine pancreatic elastase at 2.5 a resolution: comparisons with the structure of alpha-Chymotrypsin.
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Authors
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L.Sawyer,
D.M.Shotton,
J.W.Campbell,
P.L.Wendell,
H.Muirhead,
H.C.Watson.
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Ref.
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J Mol Biol, 1978,
118,
137-208.
[DOI no: ]
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PubMed id
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Figure 1.
FIG. 1. The variation in he ean arent and heavy-atom structure amplitudes and in he
accurctcy of the hase etermination of the complete high resolution tosyl-elastse data set as a
unction of sin20/ha. (-A-A-), F,//2 -O-O--), lfHl --m--W--, --O--O---,
--A--/--) and E (-m-m--, -e-a--, -b-A-) are defined as in Tables 3 and 4.
The values or wa are iven by the right ordinate, nd those or 1Frl, lfnl and E, which are n he
same non-absolute scale, by the ordinate. A, CMBS-elastase; 0, ranyl tosyl-elastase;
H, uranyl CMBS-elastase.
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Figure 10.
IG. 10. Histograms of (a) x, b) yz, (c) x3.
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The above figures are
reproduced from the cited reference
with permission from Elsevier
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