|
|
||
|
|
|
|
|
UniProt functional annotation for P45877 | ||
|
|
|
|
|
|
||
| UniProt code: P45877. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}. |
|
||
| Catalytic activity: | |
Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000269|PubMed:20676357}; |
| Activity regulation: | |
Inhibited by cyclosporin A (CsA). {ECO:0000305|PubMed:20676357}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250|UniProtKB:P30412}. |
| Tissue specificity: | |
Expressed in kidney, skeletal muscle, pancreas, heart, lung, liver and to a lower extent in brain. {ECO:0000269|PubMed:8031755}. |
| Similarity: | |
Belongs to the cyclophilin-type PPIase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.