UniProt functional annotation for Q8TD26



	UniProt functional annotation for Q8TD26

UniProt code: Q8TD26.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:28533432}.

Function: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}.

Catalytic activity: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269|PubMed:17027977};

Subunit: Interacts with NFE2L2; involved in activation of the transcription. {ECO:0000269|PubMed:16314513}.

Subunit: (Microbial infection) Interacts with the influenza A polymerase complex composed fo PB1, PB2 and PA. {ECO:0000269|PubMed:21899694}.

Subunit: (Microbial infection) Interacts (via N-terminus) with human papillomavirus protein E8^E2C (via C-terminus); this interaction induces transcriptional repression of the viral genome. {ECO:0000269|PubMed:20631145}.

Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:21899694}. Note=Enriched at sites of mRNA synthesis (PubMed:17027977). During influenza A virus infection, localizes to inactive chromatin. {ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:21899694}.

Tissue specificity: Widely expressed.

Disease: Note=A chromosomal aberration disrupting CHD6 has been found in a patient with mild to moderate mental retardation and minor facial anomalies. Translocation t(18;20)(q21.1;q11.2) with TCF4 producing a CHD6-TCF4 fusion transcript (PubMed:18627065). {ECO:0000269|PubMed:18627065}.

Similarity: Belongs to the SNF2/RAD54 helicase family. {ECO:0000305}.

Sequence caution: Sequence=AAK56405.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAN59903.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15325.1; Type=Miscellaneous discrepancy; Note=The sequence differs from position 1528 onward for unknown reasons.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269\|PubMed:16314513, ECO:0000269\|PubMed:28533432}.



Function:		(Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269\|PubMed:20631145, ECO:0000269\|PubMed:21899694, ECO:0000269\|PubMed:23408615}.


Catalytic activity:		Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269\|PubMed:17027977};
Subunit:		Interacts with NFE2L2; involved in activation of the transcription. {ECO:0000269\|PubMed:16314513}.
Subunit:		(Microbial infection) Interacts with the influenza A polymerase complex composed fo PB1, PB2 and PA. {ECO:0000269\|PubMed:21899694}.
Subunit:		(Microbial infection) Interacts (via N-terminus) with human papillomavirus protein E8^E2C (via C-terminus); this interaction induces transcriptional repression of the viral genome. {ECO:0000269\|PubMed:20631145}.
Subcellular location:		Nucleus, nucleoplasm {ECO:0000269\|PubMed:17027977, ECO:0000269\|PubMed:21899694}. Note=Enriched at sites of mRNA synthesis (PubMed:17027977). During influenza A virus infection, localizes to inactive chromatin. {ECO:0000269\|PubMed:17027977, ECO:0000269\|PubMed:21899694}.
Tissue specificity:		Widely expressed.
Disease:		Note=A chromosomal aberration disrupting CHD6 has been found in a patient with mild to moderate mental retardation and minor facial anomalies. Translocation t(18;20)(q21.1;q11.2) with TCF4 producing a CHD6-TCF4 fusion transcript (PubMed:18627065). {ECO:0000269\|PubMed:18627065}.
Similarity:		Belongs to the SNF2/RAD54 helicase family. {ECO:0000305}.
Sequence caution:		Sequence=AAK56405.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAN59903.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15325.1; Type=Miscellaneous discrepancy; Note=The sequence differs from position 1528 onward for unknown reasons.; Evidence={ECO:0000305};