UniProt functional annotation for Q14587



	UniProt functional annotation for Q14587

UniProt code: Q14587.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.

Function: [Isoform 2]: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.

Subunit: Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain); the interaction increases ZNF268 nuclear localization activity. Isoform 2 interacts with CHUK and IKBKB; the interaction is further increased in a TNF-alpha-dependent manner. {ECO:0000269|PubMed:23091055, ECO:0000269|PubMed:23665872}.

Subcellular location: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23665872}.

Subcellular location: [Isoform 2]: Nucleus {ECO:0000269|PubMed:23665872}. Cytoplasm {ECO:0000269|PubMed:23665872}.

Tissue specificity: Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. {ECO:0000269|PubMed:12200376, ECO:0000269|PubMed:16735226, ECO:0000269|PubMed:16865230, ECO:0000269|PubMed:18949428, ECO:0000269|PubMed:23091055, ECO:0000269|PubMed:23946776}.

Developmental stage: Expressed in fetal liver from 5 weeks until 4 months but drastically reduced by 6 months and became non-detectable by 7 months. Expressed in hematopoietic stem cells in 3 weeks and 5 weeks (at protein level). Expressed in fetal liver. {ECO:0000269|PubMed:15547661, ECO:0000269|PubMed:16735226}.

Induction: Down-regulated during erythroid differentiation by GATA1. Down-regulated by HTLV-1 Tax through the CREB/ATF pathway. Up-regulated by the regulator of nonsense transcript UPF1. Up-regulated by the cyclic AMP-dependent transcription factor ATF4. {ECO:0000269|PubMed:16787922, ECO:0000269|PubMed:18375384, ECO:0000269|PubMed:18774934, ECO:0000269|PubMed:22235304}.

Domain: The KRAB domain functions to reinforce the nuclear localization of isoform 1 in addition to its transcription repression activity.

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		[Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.



Function:		[Isoform 2]: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.


Subunit:		Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain); the interaction increases ZNF268 nuclear localization activity. Isoform 2 interacts with CHUK and IKBKB; the interaction is further increased in a TNF-alpha-dependent manner. {ECO:0000269\|PubMed:23091055, ECO:0000269\|PubMed:23665872}.
Subcellular location:		[Isoform 1]: Nucleus {ECO:0000269\|PubMed:23665872}.
Subcellular location:		[Isoform 2]: Nucleus {ECO:0000269\|PubMed:23665872}. Cytoplasm {ECO:0000269\|PubMed:23665872}.
Tissue specificity:		Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. {ECO:0000269\|PubMed:12200376, ECO:0000269\|PubMed:16735226, ECO:0000269\|PubMed:16865230, ECO:0000269\|PubMed:18949428, ECO:0000269\|PubMed:23091055, ECO:0000269\|PubMed:23946776}.
Developmental stage:		Expressed in fetal liver from 5 weeks until 4 months but drastically reduced by 6 months and became non-detectable by 7 months. Expressed in hematopoietic stem cells in 3 weeks and 5 weeks (at protein level). Expressed in fetal liver. {ECO:0000269\|PubMed:15547661, ECO:0000269\|PubMed:16735226}.
Induction:		Down-regulated during erythroid differentiation by GATA1. Down-regulated by HTLV-1 Tax through the CREB/ATF pathway. Up-regulated by the regulator of nonsense transcript UPF1. Up-regulated by the cyclic AMP-dependent transcription factor ATF4. {ECO:0000269\|PubMed:16787922, ECO:0000269\|PubMed:18375384, ECO:0000269\|PubMed:18774934, ECO:0000269\|PubMed:22235304}.
Domain:		The KRAB domain functions to reinforce the nuclear localization of isoform 1 in addition to its transcription repression activity.
Similarity:		Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}.