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PDBsum entry 2eb8
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Oxygen storage/transport
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PDB id
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2eb8
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References listed in PDB file
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Key reference
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Title
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Design and structure analysis of artificial metalloproteins: selective coordination of his64 to copper complexes with square-Planar structure in the apo-Myoglobin scaffold.
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Authors
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S.Abe,
T.Ueno,
P.A.Reddy,
S.Okazaki,
T.Hikage,
A.Suzuki,
T.Yamane,
H.Nakajima,
Y.Watanabe.
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Ref.
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Inorg Chem, 2007,
46,
5137-5139.
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PubMed id
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Abstract
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apo-Myoglobin (apo-Mb) was reconstituted with three copper complexes:
CuII(Sal-Phe) (1; Sal-Phe = N-salicylidene-L-phenylalanato), CuII(Sal-Leu) (2;
Sal-Leu = N-salicylidene-L-leucinato), and CuII(Sal-Ala) (3; Sal-Ala =
N-salicylidene-L-alanato). The crystal structures of 1.apo-Mb (1.65 Angstrom
resolution) and 2.apo-Mb (1.8 Angstrom resolution) show that the coordination
geometry around the CuII atom in apo-Mb is distorted square-planar with
tridentate Sal-X and a Nepsilon atom of His64 in the apo-Mb cavity and the plane
of these copper complexes is perpendicular to that of heme. These results
suggest that the apo-Mb cavity can hold metal complexes with various
coordination geometries.
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