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UniProt functional annotation for Q96LB8 | ||
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| UniProt code: Q96LB8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:16354652}. |
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| Subunit: | |
Homodimer; disulfide-linked. Heterodimer with PGLYRP3; disulfide-linked. {ECO:0000269|PubMed:16354652, ECO:0000269|PubMed:17502600}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:16354652}. |
| Tissue specificity: | |
Detected in skin epidermis, eccrine sweat glands and ducts, mucous cells in the submandibular salivary gland, mucous cells in the throat, ciliary body epithelial cells of the eye, small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). High expression in skin and esophagus. Expressed also to a much lesser extent in the tonsils and thymus. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:16354652}. |
| Induction: | |
Up-regulated by exposure to Gram-positive and Gram-negative bacteria. {ECO:0000269|PubMed:16354652}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:16354652}. |
| Similarity: | |
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAF99599.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.