PDBsum entry 2e7u

Isomerase

PDB id: 2e7u

Contents

Protein chain

424 a.a. *

Ligands

PMP

GOL

Metals

_NA ×2

Waters ×427

* Residue conservation analysis

PDB id:

2e7u

Name:

Isomerase

Title:

Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8

Structure:

Glutamate-1-semialdehyde 2,1-aminomutase. Chain: a. Synonym: gsa, glutamate-1-semialdehyde aminotransferase, gsa-at. Engineered: yes

Source:

Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.90Å R-factor: 0.180 R-free: 0.198

Authors:

H.Mizutani,N.Kunishima,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

H.Mizutani and n.kunishima Crystal structure of glutamate-1-Semialdehyde 2,1-Aminomutase from thermus thermophilus hb8. To be published, .

Date:

14-Jan-07 Release date: 17-Jul-07

Protein chain

Q5SJS4  (GSA_THET8) -  Glutamate-1-semialdehyde 2,1-aminomutase from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)

Seq: 424 a.a.

Struc: 424 a.a.

Enzyme reactions

• Enzyme class: E.C.5.4.3.8 - glutamate-1-semialdehyde 2,1-aminomutase.
• Pathway: Porphyrin Biosynthesis (early stages)
• Reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate
• Cofactor: Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate (Bound ligand (Het Group name = PMP) matches with 88.24% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site