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UniProt functional annotation for P35400 | ||
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| UniProt code: P35400. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits. {ECO:0000250|UniProtKB:Q14831, ECO:0000269|PubMed:33500274, ECO:0000269|PubMed:8145723, ECO:0000269|PubMed:8288585}. |
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| Subunit: | |
Homodimer (By similarity). Interacts with PICK1. {ECO:0000250|UniProtKB:Q14831, ECO:0000269|PubMed:11122333}. |
| Subcellular location: | |
Cell membrane {ECO:0000250|UniProtKB:Q14831}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14831}. |
| Tissue specificity: | |
Widely distributed throughout the brain. {ECO:0000269|PubMed:8145723, ECO:0000269|PubMed:8288585}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 3 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.