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UniProt functional annotation for O58056 | ||
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| UniProt code: O58056. |
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| Organism: | |
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3). |
| Taxonomy: | |
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus. |
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| Function: | |
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. {ECO:0000255|HAMAP- Rule:MF_01643}. |
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| Catalytic activity: | |
Reaction=ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate; Xref=Rhea:RHEA:24829, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143788, ChEBI:CHEBI:147286, ChEBI:CHEBI:456216; Evidence={ECO:0000255|HAMAP-Rule:MF_01643}; |
| Pathway: | |
Purine metabolism; IMP biosynthesis via de novo pathway; N(2)- formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D- ribosyl)glycinamide (formate route): step 1/1. {ECO:0000255|HAMAP- Rule:MF_01643}. |
| Subunit: | |
Homodimer. {ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000305|Ref.2, ECO:0000305|Ref.3}. |
| Similarity: | |
Belongs to the PurK/PurT family. {ECO:0000255|HAMAP- Rule:MF_01643}. |
| Sequence caution: | |
Sequence=BAA29392.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.