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UniProt functional annotation for P14604 | ||
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| UniProt code: P14604. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate. {ECO:0000269|PubMed:7883013}. |
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| Catalytic activity: | |
Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318, ChEBI:CHEBI:58856; EC=4.2.1.17; Evidence={ECO:0000250|UniProtKB:P30084}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16107; Evidence={ECO:0000250|UniProtKB:P30084}; |
| Catalytic activity: | |
Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521, ChEBI:CHEBI:137480; EC=4.2.1.17; Evidence={ECO:0000250|UniProtKB:P30084}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20726; Evidence={ECO:0000250|UniProtKB:P30084}; |
| Catalytic activity: | |
Reaction=(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O; Xref=Rhea:RHEA:26558, ChEBI:CHEBI:15377, ChEBI:CHEBI:57316, ChEBI:CHEBI:57332; Evidence={ECO:0000269|PubMed:7883013}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:26560; Evidence={ECO:0000305|PubMed:7883013}; |
| Catalytic activity: | |
Reaction=3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O; Xref=Rhea:RHEA:31079, ChEBI:CHEBI:15377, ChEBI:CHEBI:57344, ChEBI:CHEBI:62555; Evidence={ECO:0000250|UniProtKB:P30084}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31081; Evidence={ECO:0000250|UniProtKB:P30084}; |
| Catalytic activity: | |
Reaction=3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O; Xref=Rhea:RHEA:26518, ChEBI:CHEBI:15377, ChEBI:CHEBI:57367, ChEBI:CHEBI:58528; Evidence={ECO:0000250|UniProtKB:P30084}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:26520; Evidence={ECO:0000250|UniProtKB:P30084}; |
| Catalytic activity: | |
Reaction=3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O; Xref=Rhea:RHEA:45584, ChEBI:CHEBI:15377, ChEBI:CHEBI:57332, ChEBI:CHEBI:78611; Evidence={ECO:0000250|UniProtKB:P30084}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45586; Evidence={ECO:0000250|UniProtKB:P30084}; |
| Pathway: | |
Lipid metabolism; fatty acid beta-oxidation. {ECO:0000250|UniProtKB:P30084}. |
| Subunit: | |
Homohexamer; dimer of trimers. {ECO:0000269|PubMed:11851409, ECO:0000269|PubMed:12445775, ECO:0000269|PubMed:8895557, ECO:0000269|PubMed:9480773}. |
| Subcellular location: | |
Mitochondrion matrix {ECO:0000269|PubMed:9480773}. |
| Tissue specificity: | |
Detected in liver (at protein level). {ECO:0000269|PubMed:9480773}. |
| Similarity: | |
Belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.