|
|
||
|
|
|
|
|
UniProt functional annotation for P23381 | ||
|
|
|
|
|
|
||
| UniProt code: P23381. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress- responsive gene expression. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:14630953, ECO:0000269|PubMed:28369220}. |
|
||
| Catalytic activity: | |
Reaction=ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L- tryptophanyl-tRNA(Trp); Xref=Rhea:RHEA:24080, Rhea:RHEA-COMP:9671, Rhea:RHEA-COMP:9705, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57912, ChEBI:CHEBI:78442, ChEBI:CHEBI:78535, ChEBI:CHEBI:456215; EC=6.1.1.2; Evidence={ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}; |
| Subunit: | |
Homodimer (PubMed:28369220). Isoform 1 and isoform 2 interact with an oxidized form of GAPDH. GAPDH stimulates the aminoacylation activity of isoform 2 (PubMed:15628863). {ECO:0000269|PubMed:15628863, ECO:0000269|PubMed:28369220}. |
| Subcellular location: | |
Cytoplasm. |
| Induction: | |
By IFNG/IFN-gamma. {ECO:0000269|PubMed:8496617}. |
| Ptm: | |
Proteolytic cleavage generates 2 forms; T1-TrpRS and T2-TrpRS. {ECO:0000269|PubMed:11773626}. |
| Disease: | |
Neuronopathy, distal hereditary motor, 9 (HMN9) [MIM:617721]: An autosomal dominant neurologic disorder characterized by juvenile onset of slowly progressive distal muscle weakness and atrophy affecting both the lower and upper limbs. {ECO:0000269|PubMed:28369220}. Note=The disease is caused by variants affecting the gene represented in this entry. |
| Similarity: | |
Belongs to the class-I aminoacyl-tRNA synthetase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.